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Review on Clustered Regularly Interspaced Short Palindromic Repeats Technology
Summary
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) are genetic elements that bacteria use as a kind of acquired immunity to protect against viruses. They consist of short sequences that originate from viral genomes and are incorporated into the bacterial genome. The aim of the current review was to discuss and compile detail and up-to-date information about CRISPR. CRISPR is a programmable protein that can edit, eliminate, and turn on and / or off the genome like pair of scissors. It is first discovered by accident in 1987. As soon as CRISPR made its way onto the shelves and freezers of labs around the world, researchers jumped at the chance to use it. Recent one is known as CRISPR-Cas, which is short for CRISPR and CRISPR-associated protein. The new tool has taken the research world by storm, markedly shifting the line between possible and impossible. CRISPR technology is a group of technologies which has a plethora of applications on Genome editing and gene editing to enable scientists the ability to change the organism's DNA. The aim of this review paper was to discuss, compile and disseminate the technology advancement, application and challenge of CRISPER along with its current and future perspectives.
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